Journal article

Association of Epigenetic Markers of Aging With Prevalent and Incident Type 2 Diabetes

DL Li, AM Hodge, MC Southey, GG Giles, PA Dugué

The journals of gerontology. Series A, Biological sciences and medical sciences | Oxford University Press | Published : 2025

DOI: 10.1093/gerona/glaf085

Abstract

Background: Type 2 diabetes (T2D) is characterized by elevated levels of metabolic and inflammatory markers but less is known about other molecular alterations that occur with aging. We aimed to assess the associations of DNA methylation-based measures of aging (epigenetic aging) with prevalent and incident T2D in a large sample of middle-aged and older Australians. Methods: We used data from 5 403 participants in the Melbourne Collaborative Cohort Study (mean age = 59 years). Five blood-based epigen¬etic aging measures: PCPhenoAge, PCGrimAge, DNAmFitAge, bAge, and DunedinPACE were calculated. T2D status was assessed at baseline (1990-1994, Ncases= 180) and 2 waves of follow-up (1995-1998, N..

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University of Melbourne Researchers

Allison Hodge Author

Melissa Southey Author

Graham Giles Author

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Keywords

Metabolic and Endocrine

Clinical Research

2.1 Biological and Endogenous Factors

Incident Type 2 Diabetes

42 Health Sciences

Biological Aging

Epigenetic Aging

4202 Epidemiology